Doxy-PEP means taking the antibiotic doxycycline after sex, to prevent getting an STI. It is like a morning-after pill but for STIs. Taking doxy-PEP reduces your chance of acquiring syphilis, gonorrhea, and chlamydia by about two-thirds.

Two 100 mg pills of doxycycline should be taken ideally within 24 hours but no later than 72 hours after condomless sex. Condomless sex means oral, anal or vaginal/front-hole sex where a condom isn’t used for the entire time.

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Take doxycycline with plenty of water or something else to drink so that it does not get stuck when you swallow. If your stomach is upset by doxycycline, taking it with food may help. Some people are more sensitive to the sun when they take doxycycline, so wear sunscreen. Avoid dairy products, calcium, antacids, or multivitamins 2 hours before after taking doxycycline.

Does it affect normal (“good”) bacteria in our intestines? Could it increase or decrease the bacteria that live on our skin, or make them resistant to doxycycline? Will doxy-PEP increase doxycycline resistance in bacteria that cause STIs?